Centre for Applied Vision Research
  1. Visual Neuroscience and Psychophysics
  2. Ocular Optics and Instrumentation
  3. Ophthalmic Assessments and Patient Outcomes following Ophthalmic Interventions
  4. Visual Development and Plasticity
  5. Ophthalmic Public Health
  6. Measurement Techniques in Vision

Ocular Optics and Instrumentation

The Ocular Optics and Instrumentation group brings together physicists and vision scientists who develop novel methods for imaging and evaluating the eye in health and disease. The overall aim of the group is to better understand optical and neural factors that affect vision. Current projects focus on retinal imaging using structured illumination, in vitro and in vivo light scatter measurements and novel tests for acuity at photopic and mesopic light levels.

Funding has been received from research councils, charities and industry and currently supports seven research students, one research assistant and two research technicians. Research collaborations include UCL, Royal Holloway and Sheffield Universities, Qinetiq, Advanced Vision Sciences Inc and Lein Diagnostics (industry) and Moorfields Eye Hospital and Sussex Eye Hospital (NHS).


PhD Students

  • Sabah Chetty
  • Evangelia Fillippaki
  • Hannah Gillespie-Gallery
  • Yingxin Jia
  • Emily Patterson
  • Will Searle
  • Massimo Turola


2011-2015 Optimisation of mesopic illumination for residential streets. Awarded to JL Barbur, S Fotios (Sheffield) and P Raynham (UCL) EPSRC £1,220,000

2011-2014, Extension of CAD test in occupational environments. Awarded to JL Barbur and M Rodriguez-Carmona Colt Foundation £107,979

2011-2014, Minimum Colour Vision Requirements Awarded to JL Barbur UK Civil Aviation Authority £38,400

2011-2014, The effect of intraocular lens glistening on light scatter. Awarded to CC Hull Advanced Vision Science Inc £28,500

2010-2013, eyeVisor: a comprehensive portable visual testing system Awarded to S Gruppetta and D Crabb Emerald Fund. £40,000

2010, Effect of Hyperglycaemia on the ex-vivo bovine crystalline lens. Awarded to John Lawrenson CC Hull Lein Applied Diagnostics £50,101

2010-2013, Street lighting glare: a study of discomfort glare using light scatter and fMRI. Awarded to JL Barbur, P Raynham (UCL) and A Smith (RH) EPSRC £651,950

2009-2010, Early Detection of AMD and other retinal diseases. Awarded to JL Barbur Emerald Fund £10,000

2008-2009, Application of Structured Illumination Microscopy for 3-Dimensional Imaging of the Human Retina In-Vivo. Awarded to S. Gruppetta EPSRC £171,000



Gillespie Gallery H, Konstantakopoulou E, Harlow JA, and Barbur JL. (2013) Capturing age-related changes in functional contrast sensitivity with decreasing light levels in monocular and binocular vision. Invest. Ophthalmol.Vis.Sci. doi:10.1167/iovs.1312119 , 2013

Rauscher FG, Chisholm CM, Edgar DF, and Barbur JL. Assessment of novel binocular colour, motion and contrast tests in glaucoma. Cell Tissue Res. DOI 10.1007/s004410131675x, 2013


Barbur JL and Konstantakopoulou E. (2012) Changes in color vision with decreasing light level: separating the effects of normal aging from disease. J Opt Soc Am A Opt Image Sci Vis 29 (2):A27A35, 2012. doi: 10.1364/JOSAA.29.000A27

Chetty, S., Gruppetta, S. (2012) Structured illumination microscopy for in-vivo human retinal imaging: A theoretical assessment. Optics Express, 20 (23), pp. 25700-25710

Rodriguez Carmona M, O'NeillBiba M, and Barbur JL. (2012) Assessing the severity of color vision loss with implications for aviation and other occupational environments. Aviat.Space Environ.Med. 83 (No. 1):19 29, (2012)


Barbur JL and Connolly DM, (2011) "Effects of hypoxia on colour vision with emphasis on the mesopic range," Expert Rev. Ophthalmol. 6, 409 420 (2011)

Gruppetta, S., Chetty, S. (2011) Theoretical study of multispectral structured illumination for depth resolved imaging of non-stationary objects: Focus on retinal imaging  Biomedical Optics Express, 2 (2), pp. 255-263

Pelosini L, Hull C C, Boyce JF, Stamford M and Marshall J. (2011) “Optical Coherence Tomography maybe used to predict Visual Acuity in patients with Macular Oedema” submitted to Investigative Ophthalmology & Visual Science 2011 Apr 25;52(5):2741-8


Barbur JL and Stockman A, (2010) "Photopic, Mesopic and Scotopic Vision and Changes in Visual Performance," D. Dartt, J. C. Besharse, and R. Dana, eds., (Elsevier, 2010), pp. 323‐331

Barbur JL, Konstantakopoulou E, Rodriguez-Carmona M, Harlow JA, Robson AG, and Moreland JD, (2010) "The Macular Assessment Profile test a new VDU based technique for measuring the spatial distribution of the macular pigment,lens density and rapid flicker sensitivity," Ophthalmic Physiol Opt. 30, 470 483 (2010). doi: 10.1111/j.1475-1313.2010.00748.x.PMID: 20883330

Gruppetta, S. (2010) Differential amplitude scanning for refinal imaging: A theoretical study (2010) Optics Letters, 35 (17), pp. 2888-2890

Jennings BJ and Barbur JL, (2010) "Colour detection thresholds as a function of chromatic adaptation and light level," Ophthalmic Physiol Opt. 30, 560‐567 (2010)

O'Neill-Biba M, Sivaprasad S, Rodriguez-Carmona M, Wolf JE, and Barbur JL, (2010) "Loss of chromatic sensitivity in AMD and diabetes: a comparative study," Ophthalmic Physiol Opt. 30, 705-716 (2010)


Connolly DM and Barbur JL,(2009) "Low contrast acuity at photopic and mesopic luminance under mild hypoxia, normoxia, and hyperoxia," Aviat. Space Environ. Med. 80, 933-940 (2009

Hull CC. (2009) Digital Imaging and Screening for Diabetic Retinopathy. Optometry Today, pp 28-35, 8th May 2009


C Liu, S Okera, R Tandon, J Herold, C Hull, and S Thorp. (2008) Visual rehabilitation in end-stage inflammatory ocular surface disease with the osteo-odonto-keratoprosthesis: results from the UK. Br J Ophthalmol 2008;92 1211-1217. doi:10.1136/bjo.2007.130567

Connolly DM, Barbur JL, Hosking SL, and Moorhead IR, (2008) "Mild hypoxia impairs chromatic sensitivity in the mesopic range," Invest Ophthalmol. Vis. Sci. 49, 820 827 (2008)

Dalimier E, Dainty JC, and Barbur JL, (2008) "Effects of higher order aberrations on contrast acuity as a function of light level," Journal of Modern Optics 55, 791 803 (2008)

Know-Cartwright NE and Hull CC. (2008) The Biomechanics of Keratorefractive Surgery. Optometry Today, pp 30-37, 5th September 2008

Torti, C., Gruppetta, S., Diaz-Santana, L. (2008) Wavefront curvature sensing for the human eye (2008) Journal of Modern Optics, 55 (4-5), pp. 691-702